威尼斯人在线赌场

姓名 赵晓娜
职称：副教授

邮箱：[email protected]

 个人简介

赵晓娜，女，博士，副教授，硕士生导师。任中国畜牧兽医学会中兽医学分会理事，华东区中兽医研究会常任理事，山东省中兽医研究会常务副理事长，山东畜牧兽医学会中兽药创新专业委员会副会长，山东畜牧兽医学会动物生物制品和动物药品分会理事会常务理事。先后主持山东省自然科学基金面上项目2项，主持中国博士后特别资助和面上资助基金，山东省重大科技创新工程项目子课题，山东省自然科学基金青年基金，山东省博士后创新项目专项基金，教育部新教师类基金，山东农业大学青年科技创新项目各1项。参加1项公益性（农业）行业项目子课题和2项国家重点研发计划子课题的研究。在国内外学术期刊及学术会议发表学术论文28篇，以第一作者和通讯作者发表SCI论文22篇，其中一区9篇，二区8篇。作为第一发明人获得3项国家发明专利授权。主编科普图书《中兽医良方治鸡病》。参编普通高等教育“十二五”规划教材《中兽医学》。审译《（英汉对照）元亨疗马集选释-牛驼经》和《（英汉对照）元亨疗马集许序注释》。

教育经历

2016 - 2021 , 博士后 , 兽医学, 山东农业大学
2006 -2011 , 农学博士 , 临床兽医学 , 南京农业大学
2000 - 2005 , 农学学士 , 动物医学 , 河南科技学院

工作经历

2024-03 至 今, 山东农业大学, 威尼斯人在线赌场 , 副教授

2016-07 至 2024-02, 山东农业大学, 动物科技学院, 副教授

2011-07 至 2016-06, 山东农业大学, 动物科技学院, 讲师

荣誉奖励

（1）2021.10，指导硕士研究生郝佳佳完成的学位论文荣获“山东省优秀硕士学位论文”。

（2）2023.3，指导项目“桔康”——桔梗多糖免疫调节新用途探究者荣获“建行杯”第九届山东省大学生科技创新大赛二等奖。

（3）2023.3，荣获“建行杯”第九届山东省大学生科技创新大赛“银牌指导教师”荣誉称号。

（4）2023.11，荣获山东农业大学第四届“优秀班主任”荣誉称号。

执教课程

中兽医学基础、中兽医临床应用（本科生）
药理学与中兽医学、兽药创制与应用（研究生）

研究领域
      1. 中兽药药效及作用机制
      2. 中兽药研发

承担的科研项目：

1. PGPS_t靶向SPHK1调控FB1诱导猪肺泡巨噬细胞死亡的作用机制，ZR2021MC088，山东省自然科学基金面上项目，2022.1- 2024.12，主持

2. 天然防御因子兽药创制关键技术与产业化，山东省重大科技创新工程项目子课题，2019.11-2021.12，主持

3. 基于细胞自噬和凋亡研究桔梗多糖的增强免疫作用和机理，ZR2017MC026，山东省自然科学基金面上项目，2017.8- 2020.6，主持

4. 白术多糖调控巨噬细胞自噬和凋亡的作用和机理研究，中国博士后科学基金特别资助，2017T100505，2017.6-2019.6，主持

5. 桔梗多糖调控鸡腹腔巨噬细胞功能及TLR4信号通路研究，中国博士后科学基金面上项目，2016M592232，2016.3-2019.3，主持

6. 白术多糖和桔梗多糖对免疫抑制鸡Th17/Treg失衡的调节及其机制，山东省博士后创新专项基金，201603051，2016.12-2019.12，主持

7. 玉屏风活性多糖对雏鸡的免疫增强作用及机理研究，山东省自然科学基金青年基金项目，2012.7-2015.7，主持

发表文章和授权专利

     一、发表文章

     1.Xiaocheng Guo^#, Ximan Zhao^#, Linjue Li, Menglin Jiang, Aiqin Zhou, Yifan Gao, Pimiao Zheng, Jianzhu Liu^*, Xiaona Zhao^*. Platycodon grandiflorus polysaccharide inhibits the inflammatory response of 3D4/21 cells infected with PCV2. Microbial pathogenesis. 2024, 189:106592.

2. Changxi Qi ^#, Changyang Lv ^# , Menglin Jiang, Ximan Zhao, Yifan Gao, Ying Wang, Pu Zhang, Jianzhu Liu^*, Xiaona Zhao^*. The surface morphology of Atractylodes macrocephala polysaccharide and its inhibitory effect on PCV2 replication. Journal of the Science of Food and Agriculture. 2024, 104: 3624–3636.

3. Liping Li, Xufang Chen, Meiyun Lv, Ziqiang Cheng, Fang Liu, Ying Wang,Aiqin Zhou, Jianzhu Liu^*, Xiaona Zhao^*.Effect of Platycodon grandiflorusPolysaccharide on M1 PolarizationInduced by Autophagy Degradationof SOCS1/2 Proteins in 3D4/21 Cells. Frontiers in Immunology. 2022, 13:934084.

4. Xiaona Zhao, Yongxia Liu, Hongwei Wang, Wentao Li, Jianzhu Liu^*. Editorial: Xenophagy: Its role in pathogen infections. Frontiers in Cellular and Infection Microbiology. 2022, 12:1003451.  

5.Guodong Cheng^#, Shijie Zhang^#, Meiyun Lv, Changxi Qi, Rupeng Fan, Xiaocheng Guo, Jianzhu Liu^*, Xiaona Zhao*. The surface morphology of Platycodon grandiflorus polysaccharide and its anti-apoptotic effect by targeting autophagy. Phytomedicine. 2022, 103:154212.

6. Cheng Wang^#, Changxi Qi^#, Mingchao Liu, Lumei Wang, Guodong Cheng, Liping Li, Yuxiao Xing, Xiaona Zhao*, Jianzhu Liu^*. Protective effects of agrimonolide on hypoxia‐induced H9c2 cell injury by maintaining mitochondrial homeostasis. Journal of cellular biochemistry. 2022, 123(2):306-321.

6. Cheng Wang^#, Changxi Qi^#, Mingchao Liu, Lumei Wang, Guodong Cheng, Liping Li, Yuxiao Xing, Xiaona Zhao*, Jianzhu Liu^*. Protective effects of agrimonolide on hypoxia‐induced H9c2 cell injury by maintaining mitochondrial homeostasis. Journal of cellular biochemistry. 2022, 123(2):306-321.

7. Changxi Qi^#, Liping Li^#, Guodong Cheng, Bin Xiao, Yuxiao Xing, Xiaona Zhao*, Jianzhu Liu^*. Platycodon grandiforus Polysaccharide with AntiApoptosis, AntiOxidant and AntiInfammatory Activity Against LPS/DGalN Induced Acute Liver Injury in Mice. Journal of Polymers and the Environment. 2021, 29:4088-4097.

8. Shuo Zhang^#, Xiaona Zhao#, Jiajia Hao, Yiran Zhu, Yue Wang, Lumei Wang, Shuhua Guo, Hui Yi, Yongxia Liu, Jianzhu Liu^*. The role of ATF6 in Cr(VI)-induced apoptosis in DF-1 cells. Journal of Hazardous Materials. 2021, 410:124607.

9. Jiajia Hao^#, Yafen Song, Bin Tian, Changxi Qi, Liping Li, Lumei Wang, Yuxiao Xing, Xiaona Zhao*, Jianzhu Liu^*. Platycodon grandifloras polysaccharides inhibit mitophagy injury induced by Cr (VI) in DF-1 cells. Ecotoxicology and Environmental Safety. 2020, 202:110901.

10. Cheng Wang^#, Guodong Cheng, Shujuan Yang, Liping Li, Youpeng Zhang, Xiaona Zhao*, Jianzhu Liu^*. Protective effects of Platycodon grandiflorus polysaccharides against apoptosis induced by carbonyl cyanide 3-chlorophenylhydrazone in 3D4/21 cells. International Journal of Biological Macromolecules. 2019, 141:1220-1227.

11. Pimiao Zheng^#, Wentao Fan, Shenghua Wang, Pan Hao, Yang Wang, Huiyu Wan, Zhihui Hao, Jianzhu Liu^*, Xiaona Zhao*. Characterization of polysaccharides extracted from Platycodon grandifloras (Jacq.) A.DC. affecting activation of chicken peritoneal macrophages, International Journal of Biological Macromolecules. 2017, 96:775-785.  12. Xiaona Zhao#, Yuge Wang^#, Peng Yan, Guodong Cheng, Cheng Wang, Na Geng, Xuepeng Wang, Jianzhu Liu^*. Effects of Polysaccharides from Platycodon grandiflorum on Immunity-Enhancing Activity In Vitro. Molecules. 2017, 22(11): E1918.

13. Wentao Fan^#, Pimiao Zheng, Yang Wang, Pan Hao, Jianzhu Liu^*, Xiaona Zhao*. Analysis of Immunostimulatory activity of polysaccharide extracted from Yu-Ping-Feng in vitro and in vivo, Biomedicine & Pharmacotherapy. 2017, 93:146-155.

14. Wentao Fan^#, Shijie Zhang^#, Pan Hao, Pimiao Zheng, Jianzhu Liu^*, Xiaona Zhao*. Structure characterization of three polysaccharides and a comparative study of their immunomodulatory activities on chicken macrophage. Carbohydrate polymers. 2016, 153: 631-640.

15. Xiaona Zhao#, Wenjing Sun^#, Shijie Zhang, Guangju Meng, Chunhua Qi, Wentao Fan, Yuge Wang, Jianzhu Liu^*. The immune adjuvant response of polysaccharides from Atractylodis macrocephalae Koidz in chickens vaccinated against Newcastle disease (ND). Carbohydrate polymers. 2016, 141:190-196.

16. Yanhan Liu^#, Xiaona Zhao#, Xiao Zhang, Xuejun Zhao, Yongxia Liu, Jianzhu Liu^*. Effects of Oral Administration of CrCl3 on the Contents of Ca, Mg, Mn, Fe, Cu, and Zn in the Liver, Kidney, and Heart of Chicken. Biological Trace Element Research. 2016, 171:459-467.

17. Wenjing Sun^#, Kai Meng^#, Chunhua Qi, Xianyong Yang, Yuge Wang, Wentao Fan, Zhengui Yan, Xiaona Zhao^*, Jianzhu Liu^*. Immune-enhancing activity of polysaccharides isolated from Atractylodis macrocephalae Koidz. Carbohydrate polymers. 2015, 126:91-96.

18. Wentao Fan^#, Xiaona Zhao^#, Jia Cheng, Yanhan Liu, Jianzhu Liu^*. Oxidative Stress and Hepatocellular Injury Induced by Oral Administration of Cr3+ in Chicken. Journal of Biochemical and Molecular Toxicology. 2015, 29(6):280-287.

19. Xiaona Zhao^#, Jianzhu Liu^*. Scutellaria polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast. Journal of the Science of Food and Agriculture. 2014, 94(4):779-784.

20. Y Bai^#, X Zhao^#, C Qi, L Wang, Z Cheng, M Liu, J Liu^*, D Yang, S Wang, T Chai. Effects of chromium picolinate on the viability of chick embryo fibroblast. Human and Experimental Toxicology. 2014, 33(4) 403-413.

21. Xiaona Zhao^#, Yuanliang Hu^*, Deyun Wang, Jianzhu Liu, Liwei Guo. The comparison of immune-enhancing activity of sulfated polysaccharidses from Tremella and Condonpsis pilosula. Carbohydrate polymers. 2013, 98: 438-443.

22. Xiaona Zhao^#, Yuanliang Hu^*, Deyun Wang, Liwei Guo, Shujuan Yang, Yunpeng Fan, Bingkai Zhao, Yuanlei Wang, Saifuding Abula. Optimization of sulfated modification conditions of tremella polysaccharide and effects of modifiers on cellular infectivity of NDV. International Journal of Biological Macromolecules. 2011, 49:44-49. 23. 吕昌洋，范汝鹏，赵茜曼，高忆凡，蒋猛林，李林珏，郑丕苗，刘建柱，赵晓娜^*. 白术多糖对Cr(VI)诱导PK-15细胞凋亡和小鼠肾损伤的影响. 2024, 45(03):59-66.

24.肖 彬，范汝鹏，郭晓程，吕美芸，刘建柱，赵晓娜^*. 宠物犬椎间盘疾病导致后肢瘫痪的发病调查及针刺选穴治疗分析. 黑龙江畜牧兽医，2022, 14:84-88.

25. 杨笃宝，肖 彬，陈旭芳，刘 坊，周爱琴，刘建柱，赵晓娜^*. 宠物医生运用中兽医技术防治宠物犬疾病的调查分析. 山东畜牧兽医，2022, (4):9-13.

26. Xiaona Zhao^#, Yanfei Bai^#, Jianzhu Liu^*, Shujing Wang, Tongjie Chai. Essence of Traditional Chinese Medicine Syndromes Based on the Metabolomic Approach in China. International Journal of Biotechnology and Allied Fields. 2013, 1(2): 85-97.

27. 赵晓娜，牛家强，胡元亮，黄小燕，王君敏，朱广双. 12种藏药对鸡法氏囊病毒感染鸡胚成纤维细胞能力的影响. 江苏农业学报，2009, 25 (1) : 219-221.

28. 赵晓娜，牛家强，胡元亮，王君敏，黄小燕，卢宇，张帆，郑铁锁. 12种藏药对鸡胚成纤维细胞的安全浓度和生长的影响. 中国兽医学报，2009 , 29 (4) :511-513, 518.

二、授权专利

1. 赵晓娜，刘建柱，王成，程国栋. 桔梗总多糖在制备治疗由CCCP诱导的细胞凋亡的药物中的应用. ZL 201910510952.0，国家发明专利. 国家知识产权局，2022.7.1

2. 赵晓娜，刘建柱，程国栋，邓干臻，李克鑫，李克钦，刘国涛，李雯. 桔梗多糖通过自噬在拮抗伏马毒素B1诱导的细胞凋亡中的用途. ZL 2020 1 0189615.9. 国家发明专利. 国家知识产权局，2021.11.2

3. 赵晓娜，孙文静，刘建柱，马藤菲，郝盼，王胜华. 一种新城疫疫苗玉屏风多糖免疫增强剂. ZL 201510385579.2. 国家发明专利. 国家知识产权局，2018.6.5