姓名 赵宁宁
联系方式：邮箱：[email protected]；
地址：泰安市泮河大街7号山东农业大学动医大楼N506
个人简介
赵宁宁，主要从事畜禽常见寄生虫病（球虫病、弓形虫病、隐孢子虫病、滴虫病等）的研究和防控工作：包括畜禽重要寄生虫的致病机制及与宿主相互作用与共进化研究；抗畜禽寄生虫药物的筛选、开发和药物作用机制研究；兽医寄生虫病的诊断与防控等。主持国家自然科学基金，山东省自然科学基金等课题，近四年发表SCI期刊论文17篇。
教育经历
2010.09-2014.06，工学硕士，制药工程（兽药方向），山东农业大学
2014.09-2017.06，硕转博，预防兽医学，山东农业大学
2017.09-2020.06，农学博士，预防兽医学，山东农业大学
工作经历
2020.12-2023.12，博士后，畜牧学，山东农业大学动物科技学院
2024.02-至今，副教授，硕导，威尼斯人在线赌场-赌场app
执教课程
本科生课程：《动物寄生虫病学》、《动物寄生虫学实验》
研究生课程：《动物源性食品安全》、《动物传染病学与寄生虫病学》。
研究领域
畜禽常见寄生虫病（球虫病、弓形虫病、隐孢子虫病、滴虫病等）的研究和防控工作：
1.人兽共患寄生虫的致病机制及与宿主相互作用研究；
2.抗寄生虫药物与新型抗寄生虫病疫苗和制剂（益生菌及益生菌载体）的开发；
3.寄生虫病的诊断与防控。
主持和参与项目情况
1.2025.1.1-2028.12.31，国家自然科学基金青年基金项目（32402917），鸡柔嫩艾美耳球虫EtROP30介导逃避宿主I型干扰素天然免疫反应的分子机制，30.00万元，主持；
2.2024.1.1-2027.12.31，山东省自然科学基金青年基金项目（ZR2023QC165），孤儿核受体NR4A1调控RLR介导的抗病毒免疫的分子机制及在流感病毒感染中的作用，15.00万元，主持；
3.2024.2.1-2029.12.31，山东农业大学启动基金，20.00万，主持;
4.2025.01.01-2028.01.01，国家自然科学基金面上项目（32473056)），Urm1调控RON4/8介导弓形虫入侵的分子机制，50.00万，参与（第二位）；
5.2025.01.01-2025.08.01，横向，海南霉素钠、尼卡巴嗪复方制剂抗柔嫩艾美尔球虫抗球虫效果评估，20.00万，参与（第二位）。
论文发表及申请专利情况
1.Chen, H., Dai, Y., Liu J., Duan, L., Hu J., Sun S., Zhu G., Ma X., Wan J., Ma N., Zhang X., Wang C*., Zhao N*. Anti-Eimeria tenella activity of Ethanamizuril in vitro and in vivo. J Vet Med Sci. 2024;86(9):1008-1015. (通讯作者)
2.Chen, N., Cai Q., Wang S., Song Q., Xie Y., Shi H., Li H., Zhao X., Zhao N*., Zhang X*. Evaluation of the efficicacy of myrcene in the treatment of Eimeria tenella and Toxoplasma gondii infection. J Vet Med Sci. 2024. (通讯作者)
3.Bian S., Cai Q., Wang S., Xie Y., Chen N., Song Q., Li H., Zhao N*., Xiao Z*. Evaluation of the toxoplasma Urm1 gene deletion mutant (PruΔUrm1) as a promising vaccine candidate against toxoplasmosis in mice. Vaccine. 2024;45:126632. (通讯作者)
4.Sun L#., Li C#., Zhao N., Wang B., Li H., Wang H., Zhang X*., Zhao X*.. Host protein EPCAM interacting with EtMIC8-EGF is essential for attachment and invasion of Eimeria tenella in chickens. Microb Pathog. 2024;188:106549.
5.Zhao N#., Wang F#., Kong Z., Shang Y*. Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription. Viruses. 2022 Jul 2;14(7):1465.(共同一作)
6.Wang B#., Zhao N#., Sun L., Tan Q., Xiao Q., Chen J., Li J., Zhang X*., Zhao X*. A candidate virulence factor of Eimeria tenella (EtROP30) predicted by virulence enhancement of transgenic Toxoplasma gondii. Parasitol Res. 2023; 123(1):45. (共同一作)
7.Wang B#., Zhao N#., Wang Y., Sun L., Li H., Zhang X*., Zhao X*. Characterization of the Eimeria tenella rhoptry protein with a nuclear localization sequence (EtROP30). Parasitol Res. 2022; 121(5):1507-1516. (共同一作)
8.Wang B#., Zhao N#., Sun J., Sun L., Li H., Wu Z., Li H., Zhang X*., Zhao X*. Identification and Characterization of Eimeria tenella Rhoptry Protein 35 (EtROP35). Vet Sci. 2022; 9(9):465. (共同一作)
9.Chen X., Sun P., Chen J., Tan Q., Li J., Liu X., Xiao Q., Li H., Zhao X., Zhao N*., Zhang X*. Epidemiological investigation and reinfection evaluation of Toxoplasma gondii in chickens in Shandong Province, China. Exp Parasitol. 2022; 238:108276. (通讯作者)
10.Sun L., Zhao N., Li H., Wang B., Li H., Zhang X*., Zhao X*. Construction of a Lactobacillus plantarum-based claudin-3 targeting delivery system for the development of vaccines against Eimeria tenella. Vaccine. 2023; 41(3):756-765.
11.Sun L., Lu Y., Zhao N., Wang Y., Wang B., Li H., Wu Z., Li H., Zhang X*., Zhao X*. Construction of constitutive expression of Eimeria tenella eukaryotic initiation factor U6L5H2 on the surface of Lactobacillus plantarum and evaluation of its immunoprotective efficiency against chicken coccidiosis. Mol Biochem Parasitol. 2022; 252:111527.
12.Zhao N., Ming S., Sun L., Wang B., Li H., Zhang X., Zhao X. Identification and Characterization of Eimeria tenella Microneme Protein (EtMIC8). Microbiol Spectr. 2021; 9(1):e0022821.(第一作者)
13.Zhao N., Lv J., Lu Y., Jiang Y., Li H., Liu Y., Zhang X., Zhao X. Prolonging and enhancing the protective efficacy of the EtMIC3-C-MAR against eimeria tenella through delivered by attenuated salmonella typhimurium. Vet Parasitol. 2020; 279:109061.(第一作者)
14.Wang R#., Zhao N#., Zhang H., Wang F., Li H., Liu Y., Zhao X., Zhang X.Prevalence of Toxoplasma gondii Infections in Chicken Hearts from Farmers' Markets and Supermarkets in the Tai'an Region of China. J Food Prot. 2020; 83(2):338-341.(共同一作)
15.Zhao N., Jiang Y., Ming S., Liu S., Zhao X*., Wang F*.Monoclonal Antibody Preparation and Epitope Identification for Brucella melitensis Elongation Factor Tu. Front Microbiol. 2019; 10:1878.(第一作者)
16.Zhao N., Ming S., Lu Y., Wang F., Li H., Zhang X., Zhao X*. Identification and Application of Epitopes in EtMIC1 of Eimeria tenella Recognized by the Monoclonal Antibodies 1-A1 and 1-H2. Infect Immun. 2019; 87(11):e00596-19.(第一作者)
17.Chen Z., Wang X., Zhao N., Han L., Wang F., Li H., Cui Y., Zhao X*. Improving the immunogenicity and protective efficacy of the EtMIC2 protein against Eimeria tenella infection through random mutagenesis. Vaccine. 2018;36(18):2435-2441.
18.王方昆; 赵孝民; 李宏梅; 刘思当; 赵宁宁；马耳他型布氏杆菌的EF-Tu蛋白单克隆抗体MAb及其制备方法与应用。CN105218668B，2020-03-24。